Regarding Link Detox, links it diagnoses as Toxic are generally fine as they're either not indexed by Google or have malware/viruses/etc., but I recommend a manual review of any diagnosed as Suspicious. I used it recently to get started cleaning up our backlinks and some legit sites and blogs were under Suspicious simply because they didn't have many links pointing to them.
Using organic search data through Data Cube you can make your PPC campaign even stronger. You can research keywords that have the highest traffic and use the BrightEdge Recommendations engine to learn the types of sites that people are most likely targeting with specific queries. You can then create content for your PPC campaigns armed with this insight, positioning yourself well for paid search success.