Regarding Link Detox, links it diagnoses as Toxic are generally fine as they're either not indexed by Google or have malware/viruses/etc., but I recommend a manual review of any diagnosed as Suspicious. I used it recently to get started cleaning up our backlinks and some legit sites and blogs were under Suspicious simply because they didn't have many links pointing to them.
Remember when you used to rely solely on search engines for traffic? Remember when you worked on SEO and lived and died by your placement in Google? Were you #1? Assured success. Well, okay, maybe not assured. Success only came if the keywords were relevant to your site users, but it was the only real roadmap to generating site traffic and revenue.