For our client: We were lucky enough to remove most from the prior agency outreach, we also went directly to many webmasters in which we wanted to remove links. We did not use the Disavow tool as it was not around when we completed this link cleanup, but we all know it has been said that if you are going to use the Disavow Tool to use it with caution.
Remember when you used to rely solely on search engines for traffic? Remember when you worked on SEO and lived and died by your placement in Google? Were you #1? Assured success. Well, okay, maybe not assured. Success only came if the keywords were relevant to your site users, but it was the only real roadmap to generating site traffic and revenue.